MT-1

1. Basic Product Information

1. Catalog Code: MT-1
2. Chemical Name: MT-1, Afamelanotide, [Nle4,D-Phe7]-α-MSH
3. Specification: 10mg per vial
4. Appearance: White sterile lyophilized polypeptide powder
5. Purity: Research grade ≥99% (HPLC verification)
6. CAS Number: 75921-69-6
7. Molecular Weight: 1646.87 Da
8. Amino Acid Sequence: Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val
9. Target: MT-1 Receptor (MC1R)

2. Mechanism of Action

MT-1 is a linear synthetic analog of endogenous α-MSH (alpha-melanocyte stimulating hormone).

1. Highly selective agonist for MC1R on melanocytes; far more receptor-selective thanMT-1
2. Activates melanocytes to stimulate melanin synthesis and deposition.
3. Increased skin melanin improves natural UV radiation resistance, reducing photodamage.
4. Minimal activation of MC3R / MC4R / MC5R, so fewer extra side effects compared with MT2 in laboratory studies.

5. Research Observed Effects (Laboratory Reference Only)

1. Pigmentation research: Study melanogenesis pathway, skin tanning mechanism.
2. Photoprotection research: Explore prevention of UV-induced skin injury, photosensitivity disorders.
3. Dermatology research: Experimental model for vitiligo and pigment-related skin diseases.
4. MT-1 receptor pharmacology research for drug development.

Potential Risks of Bulk Lyophilized Powder

1. No GMP pharmaceutical-grade sterility guarantee. Self-reconstitution injection may trigger subcutaneous infection and abscess.
2. Possible adverse reactions for off-label human use: nausea, facial flushing, increased pigmentation of moles/freckles.
3. Long-term safety data for unsupervised human use remains insufficient.
4. Uncontrolled impurities and non-pharmaceutical excipients may induce allergies and organ burden.
5. Legal reminder: Limited to laboratory research only. Unauthorized human administration and illegal resale violate drug supervision regulations.

5. Storage Specifications

• Dry powder long-term storage: -20℃, sealed, protected from light, avoid repeated freeze-thaw cycles
• After reconstitution: Store at 2~8°C and use within a short period